Recent studies indicate cells transfer between fetus and mother during
pregnancy and can persist in both decades later. The presence within one individual
of a small population of cells from another genetically distinct individual
is referred to as microchimerism. Naturally acquired microchimerism has recently
been investigated in autoimmune diseases, including scleroderma, thyroiditis,
primary biliary cirrhosis, Sjögren syndrome, systemic lupus, dermatomyositis,
and neonatal lupus. Iatrogenic chimerism has been investigated in transplantation
and following blood transfusion. Considering findings of naturally acquired
microchimerism along with iatrogenic microchimerism suggests microchimerism
can have detrimental and/or beneficial effects in both settings. Recent identification
of tissue-specific microchimerism either from naturally acquired or iatrogenic
microchimerism (eg, cardiac myocytes) raises the possibility that microchimerism
can be a target of autoimmunity or alternatively contribute to tissue repair.
Advances in this new frontier of research with varied and numerous implications
for human health are summarized.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 118
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.