Early identification of patients at risk of kidney disease could slow
or prevent disease sequelae. Fox and colleagues examined the predictors of
incident kidney disease in participants enrolled in the Framingham Offspring
Study, a community-based, longitudinal cohort study. They found that established
cardiovascular risk factors including older age, diabetes, hypertension, obesity,
cigarette use, low levels of high-density lipoprotein cholesterol, and mild
reductions in glomerular filtration at baseline were associated with new-onset
kidney disease during a mean follow-up of 18.5 years.