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Physicians Apply Genome Research to Treating Critical Illness and Injury

Tracy Hampton, PhD
JAMA. 2004;291(3):287-288. doi:10.1001/jama.291.3.287.
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A microarray determining which of thousands of genes in leukemia cells were expressed at a higher (red) or lower (green) level after treatment with two cancer drugs alone or in combination revealed 124 genes that respond differently to four regimens: (1) high-dose methotrexate (HDMTX), (2) HDMTX plus mercaptopurine (MP), (3) MP, or (4) low-dose methotrexate (LDMTX) plus MP. Boxes enclose the five genes that were most up-regulated (increased in gene expression) and the five genes that were most down-regulated (decreased in gene expression) with each treatment when compared with the other three regimens (Nat Genet. 2003;34:85-90). Differences in response to drug combinations vs single agents may be useful in many areas of medicine, including critical care. (Photo credit: William E. Evans, PharmD)



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