Outbreaks of enterovirus 71 have been associated with serious morbidity
and mortality. Lin and colleagues conducted a prospective family cohort study
in Taiwan to investigate enterovirus 71 transmission and determine clinical
outcomes within households of patients infected with enterovirus 71. Household
transmission rates of enterovirus 71 were significantly higher among children
than among adults. Infection of household children, especially those younger
than 3 years, was associated with serious complications, sequelae, and death,
whereas infection of adults was usually asymptomatic or mild.