For more than 50 years, it has been known that atherosclerosis begins
in childhood and progresses through adolescence and young adulthood to cause
coronary heart disease (CHD) in middle age and later.1 Although
previously considered an inevitable consequence of aging, atherosclerosis
is now thought to be caused by a number of genetic-environmental interactions.
Risk factors, including intervening variables (eg, elevated levels of low-density
lipoprotein cholesterol [LDL-C]) and environmental exposures (eg, cigarette
smoking) predict the incidence of CHD in adulthood and are associated with
advanced atherosclerotic lesions. A vast body of knowledge about the molecular
and cellular biology of atherosclerosis now provides plausible mechanisms
for a causal relationship among risk factors, atherogenesis, and clinical
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 42
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.