0
Editorial |

Race and Outcome in Childhood Acute Lymphoblastic Leukemia

William L. Carroll, MD
JAMA. 2003;290(15):2061-2063. doi:10.1001/jama.290.15.2061.
Text Size: A A A
Published online

Extract

The dramatic improvement in overall survival for childhood acute lymphoblastic leukemia (ALL) is one of the most notable achievements to date in the fight against cancer. In the 1960s, only 15% of children survived 5 years from time of diagnosis, whereas today more than 80% of children are cured.1,2 Many factors have led to these remarkable results, including identification of agents active in the treatment of ALL, recognition of sanctuary sites with routine administration of preventive central nervous system–directed therapy, increasing emphasis on risk-adapted therapy in which treatment is tailored to predictive clinical and biological variables, and more recently intensification of treatment. Participation in clinical trials, a hallmark of pediatric oncology, identifies the most successful components of therapy and ensures that all children receive the most advanced, up-to-date treatment. However, not all children have benefited equally from this progress. Many reports have documented that children of certain race/ethnic groups have inferior outcomes. Two reports in this issue of THE JOURNAL focus on this issue and illustrate some of the challenges of investigating multifaceted clinical relationships.3,4

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 10

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();