Bipolar disorder, one of the most common severe mental illnesses, includes
type 1 (with mania and usually recurrent depression) and type 2 (recurrent
major depression with hypomania).1,2 Lifetime
prevalence for type 1 bipolar disorder is approximately 1%, but inclusion
of more broadly defined conditions increases this rate to 2% to 5%.3 Bipolar disorder can begin in childhood or adolescence,4 continues throughout life, and is extraordinarily
costly—financially as well as clinically and socially.5 The
course of bipolar disorder is episodic but highly variable, with potential
for high levels of severity and recurrence intensity, disproportionately high
depressive morbidity, and comorbidity with substance abuse and anxiety disorders.3 Bipolar depression can be present during 20% to 30%
of patients' time, even during prophylactic treatment,6- 8 and
is closely associated with disability and mortality.3,9,10 Bipolar
disorder proves fatal in a high proportion of patients from complications
of risk-taking behavior, comorbid stress-sensitive medical illnesses, and
especially suicide.3,9,10 These
characteristics mark bipolar disorder as a major unsolved public health challenge.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 57
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.