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Letters |

Vascular Effects of Cocoa Rich in Flavan-3-ols

Christian Heiss, MD; André Dejam, MD; Petra Kleinbongard; Tankred Schewe, PhD; Helmut Sies, MD, PhD; Malte Kelm, MD, PhD
JAMA. 2003;290(8):1030-1031. doi:10.1001/jama.290.8.1030.
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Figure 1. Time Course of Flow-Mediated Dilation After Ingestion of 100 mL of Cocoa Drink Containing High (176 mg mL; n = 6) or Low (<10 mg mL; n = 3) Amounts of Flavan-3-ols
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Data given as mean (SEM). *Indicates significant difference from baseline (P<.001).
Figure 2. Effects of Cocoa Drink Containing Low (<10 mg/100 mL) or High (176 mg/100 mL) Amounts of Flavan-3-ols on Plasma Nitric Oxide Pool and Flow-Mediated Dilation
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Nitric oxide pool was measured as the nitrosylated and nitrosated species collectively referred to as RNO (S-nitrosothiols, N-nitrosoproteins). Ingestion of 100 mL of the cocoa drink rich in flavan-3-ols increased RNO concentrations and flow-mediated dilation significantly over the controls. Squares indicate means; error bars, SEM. *Indicates significant difference from baseline (P<.001).



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