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Editorial |

Combined Hormone Therapy and Breast Cancer:  A Single-Edged Sword

Peter H. Gann, MD, ScD; Monica Morrow, MD
JAMA. 2003;289(24):3304-3306. doi:10.1001/jama.289.24.3304.
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The Women's Health Initiative (WHI) trial of estrogen plus progestin hormone therapy represents a major landmark in medical research. The study demonstrates that alteration of a woman's basic hormonal physiology over decades in the interest of long-term disease prevention is fraught with hazard.1 The WHI investigators terminated the trial after an assessment of the overall risk-benefit ratio of this combined hormone therapy regimen failed to demonstrate a benefit. A statistically significant 26% increase in breast cancer incidence contributed to the overall negative effect of estrogen plus progestin.1

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