In 1994, the development of bivalirudin, a novel direct thrombin inhibitor,
was precipitously suspended by the manufacturer based on an unfavorable economic
analysis comparing bivalirudin with heparin in patients undergoing angioplasty.1- 4 However,
the convergence of several events over the last 8 years maintained interest
in this agent: a new, less expensive manufacturing process was developed;
the drug was licensed to a new sponsor in 1997; and the original angioplasty
trial was reanalyzed with its results cast in a more favorable light.5,6 Now, in this issue of THE JOURNAL,
the investigators of the Randomized Evaluation in PCI Linking Angiomax to
Reduced Clinical Events (REPLACE)–2 trial7 suggest
that clinicians should consider bivalirudin as the core anticoagulant in patients
undergoing a percutaneous coronary intervention (PCI).
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 20
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.