0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correction |

Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)—Correction FREE

JAMA. 2002;288(23):2976. doi:10.1001/jama.288.23.2976.
Text Size: A A A
Published online

Corrected Data. In the Original Contribution entitled "Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)" published in the April 19, 2000, issue of THE JOURNAL (2000;283:1967-1975), data that were reported have since been corrected. The original reported number of 42 448 participants and 625 sites changed because 30 patients with poor documentation of informed consent were excluded. This also changed the original reported numbers of 15 268 participants in the chlorthalidone group and 9067 participants in the doxazosin group (a total of 24 335) to 15 255 and 9061, respectively (a total of 24 316). In addition, the original article reported a sample size of 10 337 for the lipid-lowering trial component of ALLHAT. This was a typographical error and should have been 10 357. However, due to the deletion of participants from the database, this number is now 10 355.

In addition, losses to follow-up were reported as 501 patients in the chlorthalidone group and 338 patients in the doxazosin group. This has been changed to losses of 545 patients and 361 patients, respectively, because the authors modified the definition of loss to follow-up. Originally, the definition was based on declaration of loss by a clinic site. The new definition includes this plus vital status unknown at trial closeout, the period of October 15, 1999, through February 15, 2000.

Deaths were ascertained through February 15, 2000, by clinic report or by match with an entry in databases from the Center for Medicare and Medicaid Services, the Department of Veterans Affairs, the National Death Index, or the Social Security Administration with a confirmatory death certificate. The additional lost individuals were not known to be dead or to have had a closeout visit after October 15, 1999. The authors identified additional deaths in both the doxazosin (n = 769) and chlorthalidone (n = 1258) groups before the cutoff date of February 15, 2000.

Despite these changes, the outcome analyses remain essentially the same and all statistically significant results remain so.

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.