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Perspectives on Care at the Close of Life | Clinician's Corner

Alzheimer Disease "It's Okay, Mama, If You Want to Go, It's Okay"

Ann C. Hurley, RN, DNSc; Ladislav Volicer, MD, PhD
JAMA. 2002;288(18):2324-2331. doi:10.1001/jama.288.18.2324.
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About 4 million people in the United States have Alzheimer disease (AD) and the number of incident cases is expected to more than double from 377 000 in 1995 to 959 000 in 2050. Patients, their families, and health care professionals struggle with a relentless and irreversible neurological syndrome that can last from 2 to 20 years. Alzheimer disease causes both cognitive and functional impairments that predispose the patient to behavioral symptoms, destroy intellectual capacity and personality, erase the ability to communicate one's wishes for care, and lead to life-threatening consequences. At the close of life, family members and clinicians face decisions regarding degrees of intensive medical care to be provided for treatment of the late-stage consequences of AD, including withdrawal of invasive interventions, initiation of hospice, and treatment of a range of progressive medical conditions. Physicians can assist patients with AD and their loved ones through the terminal phases of the illness by preparing them for the relentless progression of the disease and by supporting them through the intellectual and emotional conflicts accompanying the end of life.

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Figure. Progressive Decline Observed in Alzheimer Disease
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Reprinted with permission from Volicer and Hurley.17



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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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