The risk of acquiring Alzheimer disease (AD) is considerable in countries
with long life expectancies. Projected national burdens related to AD are
daunting as unprecedented numbers of people are expected to survive their
eighth and ninth decades of life.1 In the United
States, the current estimate of 360 000 new cases of AD each year is
expected to triple in the next 40 years.2 Even
modestly effective interventions that delay the onset of AD by 1 to 3 years
will substantially alleviate the growing economic and societal burden associated
with this disease.3
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