Context Ongoing efforts to improve the quality of reporting for randomized controlled
trials (RCTs) include the Consolidated Standards of Reporting Trials (CONSORT)
statement. We examined the frequency of explicit reporting of the number needed
to treat (NNT) and the absolute risk reduction (ARR) in RCTs.
Methods Five frequently cited journals were investigated: Annals of Internal Medicine, BMJ, JAMA, The Lancet, and the New England Journal
of Medicine. For each journal, 4 years were evaluated: 1989, 1992,
1995, and 1998. All issues of each journal for each year were reviewed manually.
Eligible articles were those in which an RCT was conducted on the use of a
medication showing a significant treatment effect. Elements abstracted from
each eligible article were the condition investigated, event being treated
or prevented, intervention, study results, and reporting methods (relative
risk reduction, NNT, and ARR).
Results Of 359 eligible articles, NNT was reported in 8 articles. Six of the
8 studies were from 1998. Absolute risk reduction was reported in 18 articles,
10 of which were from 1998.
Conclusions Despite CONSORT recommendations, few authors expressed their findings
in terms of NNT or ARR. Consideration should be given to including these values
in reports of RCTs.