For men, the average number of annual smoking-attributable cancer deaths during 1995-1999 decreased by approximately 1,100 (to 102,812 deaths) from 1990-1994; the number of cardiovascular disease deaths fell by approximately 28,000 (to 90,906 deaths), and the number of respiratory disease deaths remained stable (53,713 deaths). For women, the average number of annual smoking-attributable cancer deaths during 1995-1999 increased by approximately 5,800 (to 54,664 deaths), the number of respiratory disease deaths increased by approximately 7,300 (to 44,429 deaths), and the number of cardiovascular disease deaths fell by approximately 5,400 (to 57,699 deaths). Compared with 1990-1994, during 1995-1999, the average number of annual smoking-attributable deaths from perinatal conditions fell from 926 to 598 for males and from 666 to 407 for females. Excluding adult deaths from secondhand smoke, each year SAM was responsible for an estimated 3,332,272 YPLL for men and 2,284,113 for women. Adult male and female smokers lost an average of 13.2 and 14.5 years of life, respectively, because they smoked.