0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Placebo in Clinical Trials for Depression:  Complexity and Necessity

David J. Kupfer, MD; Ellen Frank, PhD
JAMA. 2002;287(14):1853-1854. doi:10.1001/jama.287.14.1853.
Text Size: A A A
Published online

Extract

Within the last several years, the long-simmering debate about the ethical issues surrounding placebo administration in randomized clinical trials has reached new levels of intensity. The report of the National Bioethics Advisory Commission included specific recommendations for studies involving more than minimal risk, including the use of placebo controls in clinical trials.1 At a time of increased interest in drug discovery in medicine and the potential need for definitive randomized clinical trials, the controversy over the ethical issues places an appropriate burden on the scientific community to justify the use of placebo controls.2,3 One argument is that placebo administration is not appropriate if effective treatment for a condition exists and that assessment of efficacy can be conducted with active controls. Another view is that placebo controls may be necessary to determine the assay sensitivity of a trial and are ethical if patients provide informed consent and are not harmed.4

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 35

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

Care at the Close of Life: Evidence and Experience
Depression

Care at the Close of Life: Evidence and Experience
Treatment of Depression

brightcove.createExperiences();