San Diego—Estrogen is a hormone adept at multitasking. Not only does this ubiquitous molecule influence reproduction, it plays a role in bone and mineral metabolism, cardiac and vascular function, and various aspects of cognition, such as memory. But discovering the ways in which estrogen wields its influence in various organ systems such as the brain has been challenging.
Over the years basic research has suggested mechanisms by which estrogen contributes to brain functioning, but clinical studies have produced conflicting results. For example, a randomized, double-blind, placebo-controlled study showed that estrogen replacement therapy given for 1 year did not slow cognitive decline in women with mild to moderate Alzheimer disease (AD) who have had hysterectomies (JAMA. 2000;283:1007-1015). And a meta-analysis of studies evaluating hormone replacement therapy (HRT) for prevention of cognitive decline showed that HRT may have beneficial cognitive effects in women with menopausal symptoms but not in asymptomatic women (JAMA. 2001;285:1489-1499).
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.