In this issue of THE JOURNAL, Feskanich and colleagues1
report that women enrolled in the Nurses' Health Study (NHS) who had the highest
intake of vitamin A and, specifically, retinol had higher rates of nontraumatic
hip fracture than women with the lowest intake. This association raises important
questions on the safety of long-term ingestion of dietary retinol. But should
these observations alter recommendations for retinol or provitamin A intake
from foods, fortified foods, and supplements? To answer, the sources and functions
of dietary vitamin A must be considered.
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