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Editorial |

Tau and Parkinson Disease

Maria Grazia Spillantini, PhD; Michel Goedert, MD, PhD
JAMA. 2001;286(18):2324-2326. doi:10.1001/jama.286.18.2324.
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Filamentous deposits made of the microtubule-associated protein tau are a defining characteristic of a number of neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and some frontotemporal dementias, such as Pick disease.1 The identification of coding region and intronic (noncoding) mutations in the tau gene in familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has established that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.24

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