The Framingham coronary heart disease (CHD) prediction functions, developed
to predict the risk of clinical CHD events, were based on data from the Framingham
Heart Study, which enrolled only white middle-class individuals. To evaluate
the generalizability of the prediction functions, D'Agostino and colleagues
applied them to 6 prospectively studied, ethnically diverse cohorts, including
whites, blacks, Native Americans, Japanese American men, and Hispanic men.
The Framingham functions performed well for white men and women and for black
men and women in different settings within 5 years of follow-up. After recalibration
for different prevalences of risk factors and underlying rates of CHD events,
the Framingham functions also performed well for other ethnic groups.