Schizophrenia is a devastating disorder affecting 1% of the population
worldwide.1 Typically presenting in adolescence
or young adulthood, schizophrenia is characterized by major disruptions of
thinking (delusions, disorganization), perception (hallucinations), mood,
and behavior.2 Symptoms tend to persist without
treatment. The elucidation of the biology of schizophrenia will constitute
a development of great medical and historic importance. The study of familial
schizophrenia was instrumental in opening the field of psychiatry to genetic
inquiry, and together with twin and adoption studies helped forge the field
of psychiatric genetics. Over the past century, studies have consistently
shown that both genetic and nongenetic factors play a significant role in
the etiology of schizophrenia.
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