The remarkable half-century transition of whole organ transplantation
from experimental intervention to standard clinical practice has resulted
in a growing disparity between the number of persons who could potentially
benefit from allotransplants and the availability of transplantable human
organs.1 This disparity inspired initial attempts
to explore alternative therapies for organ failure, among them xenotransplantation,
which involves the use of living, nonhuman animal tissues in humans.
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