Proteus syndrome is a rare and sporadic disorder that causes postnatal
overgrowth of multiple tissues in a mosaic pattern. The overgrowth can involve
skin, subcutaneous tissue, connective tissue (including bone), the central
nervous system, and viscera. Complications of Proteus syndrome include, among
others, progressive skeletal deformities, invasive lipomas, benign and malignant
tumors, and deep venous thrombosis with pulmonary embolism. Care of patients
with Proteus syndrome presents significant challenges to both physicians and
parents because of the various medical as well as psychosocial consequences
of the disease. Herein, the case of a 5-year-old patient who manifested a
number of these complications is presented. Current knowledge about the diagnosis,
natural history, etiology, and management of the disorder is reviewed.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 43
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.