Numerous epidemiological studies have shown that light to moderate drinkers
of alcohol are at lower risk than abstainers for fatal or nonfatal coronary
heart disease (CHD). A recent meta-analysis1
that included 51 (43 cohort) studies estimated a 20% risk reduction for consumption
of 0 to 20 g of alcohol (0-2 drinks) per day and some risk reduction for intake
up to 72 g (6 drinks) per day. The lower CHD risk in drinkers also has been
observed in a wide variety of patient populations, including those with diabetes,2,3 hypertension,4,5
and prior myocardial infarction (MI).6 The
consistency of these findings and the growing evidence that alcohol might
protect against CHD via higher high-density lipoprotein (HDL) cholesterol
levels, antithrombotic actions, or reduced insulin resistance argue for a
causal protective effect of moderate drinking.7- 11
Genetic factors probably play an important role, for example, moderate drinkers
who are homozygous for the ADH3 allele (associated
with slower rate of ethanol metabolism) have higher HDL levels and decreased
risk of MI.12
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 30
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.