Author Contributions: Dr Knight had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Muhlestein, Lappé, Lima, May, Towner, Anderson.
Acquisition, analysis, or interpretation of data: Muhlestein, Lappé, Lima, Rosen, May, Knight, Bluemke, Le, Bair, Vavare, Anderson.
Drafting of the manuscript: Muhlestein, Lappé, Lima, Knight, Anderson.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: May, Knight.
Obtained funding: Muhlestein, Lappé, Anderson.
Administrative, technical, or material support: Muhlestein, Lappé, Lima, Bluemke, Anderson.
Study supervision: Muhlestein, Lappé, Lima, Anderson.
Adjudication of cardiac events: Muhlestein, Le, Anderson.
Published Online: November 17, 2014. doi:10.1001/jama.2014.15825.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was performed with the support of the Intermountain Research and Medical Foundation, Intermountain Healthcare Urban Central Region, Salt Lake City, Utah, and the Intermountain Heart Institute Department of Cardiovascular Research. In addition, the FACTOR-64 study was supported by grants from Toshiba Corporation and Bracco Corporation.
Role of the Funders/Sponsors: The industrial sponsors had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Independent Data Monitoring Committee: Steven C. Horton, MD, Benjamin D. Horne, PhD, MPH, John F. Carlquist, PhD, Intermountain Heart Institute, Salt Lake City, Utah.
Additional Contributions: We express sincere appreciation to the physicians who acted as volunteer readers of the FACTOR-64 coronary computed tomography angiograms, including Thomas R. Bonk, MD, Ritesh Dhar, MD, Todd D. Lovelace, MD, Christopher J. McGann, MD, Brent D. Wilson, MD, PhD, and Kevin J. Walsh, MD. We also thank Lisa Bredthauer, Kyle Balling, BS, Kenneth D. Horton, RCS, Anna French, BS, Angela Schwab, MS, Patti Spencer, BS, Farangis Lavasani, RN, Brianna S. Ronnow, MS, and Ben Chisum of the Intermountain Heart Institute Cardiovascular Research Program for their indispensable assistance in clinical research coordination or supervision. We also thank all of the referring and primary care physicians of the FACTOR-64 patients and our study enrollees for their essential contributions.