The research by Koch and colleagues1
reported in this issue of THE JOURNAL addresses an important clinical question:
Why do some people get more infections than others? There are numerous examples
of genetically determined variations in the human immune system that influence
the ability to respond effectively to the challenges that microorganisms present.
The most obvious are the genetically determined primary immunodeficiency diseases.
These complete deficiencies of one or another component of the immune system,
such as X-linked agammaglobulinemia, markedly increase susceptibility to a
wide variety of infections.2 However, these
uncommon and dramatic deficiencies of the immune system are only 1 example
of genetically determined variations in the immune system that can lead to
increased susceptibility to infection.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 6
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.