Published Online: November 15, 2014. doi:10.1001/jama.2014.15284.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Garg.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Garg, Cuerden.
Obtained funding: All authors.
Administrative, technical, or material support: All authors.
Study supervision: Garg, Sessler, Yusuf, Devereaux.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Parikh reported receiving personal fees for serving as a consultant to Abbvie. Dr Font reported receiving personal fees from Johnson & Johnson. Dr Amir reported receiving an institutional grant from the Population Health Research Institute in Canada. Dr Walsh reported receiving a peer-reviewed grant from the Canadian Institutes of Health Research. Dr V. Chan reported receiving personal fees from Abbvie, Philips, and Smiths Medical; and equipment support from Analogic Ultrasound. Dr Yusuf reported receiving grants and personal fees from Boehringer Ingelheim and Bayer; and only receiving grants from AstraZeneca, GlaxoSmithKline, sanofi-aventis, Cadila, and Bristol-Myers Squibb. Dr Devereaux reported receiving grants from Abbott Diagnostics, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Covidien, Roche Diagnostics, and Stryker. No other disclosures were reported.
Funding/Support: The Perioperative Ischemic Evaluation-2 (POISE-2) Trial and this acute kidney injury substudy were financially supported by grants from the Canadian Institutes of Health Research. Financial support for POISE-2 was also provided by the Australian National Health and Medical Research Council and the Spanish Ministry of Health and Social Policy. Boehringer Ingelheim provided the clonidine study drug and some funding. Bayer Pharma AG provided the aspirin study drug.
Role of the Funders/Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.
POISE-2 Investigators: The following list includes investigators who participated in the acute kidney injury substudy of POISE-2 by country: Argentina: A. Alvarez. Australia: R. Bulach, S. Hannon, K. Ives, A. Jeffreys, S. Lang, G. Ludbrook, P. Myles, C. Osborne, T. Painter, B. Riedel, S. Sawhney, and P. Sivalingam. Austria: E. Fleischmann, B. Kabon, F. Luf, and M. Radonic. Belgium: S. Bidgoli, S. De Hert, M. De Kock, S. Hublet, P. Van der Linden, and P. Forget. Brazil: R. R. Bergo, O. Berwanger, P. Duarte, and D. Gualandro. Canada: S. Abbas, R. Allard, W. Beattie, V. Chan, D. Chauret, K. Chin, D. Cook, W. Dechert, E. de Medicis, G. Dresser, D. Dumerton-Shore, H. El Beheiry, A. Garg, M. Graham, K. Gregus, M. Gros, D. Hornstein, P. Jackson, P. Jones, R. Lavi, K. Lawrence, P. Li, J. McCourt, S. McMullen, R. Mizera, R. Moor, D. Ong, J. Parlow, M. Raazi, O. Regalado, T. Schricker, V. Schumann, J. Shin, S. Srinathan, M. Tiboni, A. Todd, T. VanHelder, and D. Wijeysundera. Chile: X. Jara, P. Leon, and D. Torres. Colombia: O. Cortes, F. Montes, G. Parra, M. Rojas, R. Plata, F. Romero, S. Vasquez, and J. Villar. Denmark: N. Bauer, M. Bøgeskov, R. Dahl, M. Madsen, K. Martinsen, and E. Søndergaard. France: P. Alfonsi, P. Coriat, P. Diemunsch, and V. Piriou. Germany: A. Hoeft, U. Kaisers, and T. Treschan. Hong Kong: M. Chan, G. Choi, T. Gin, and P. Chiu. India: V. Abraham, K. Agarwal, S. Gaikwad, B. Mehra, N. Mohan, B. Premendaran, and G. Sidhu. Italy: R. Lembo, L. Pasin, and S. Passarani. Malaysia: H. Lee. New Zealand: K. Jamieson, S. Olliff, and S. Walker. Pakistan: M. Amir, O. Ishtiaq, and J. Safdar. Peru: A. Acuna-Villaorduna, P. Barrionuevo, and A. Castaneda-Guarderas. South Africa: B. Biccard, B. Diedericks, L. Drummond, and P. Naidoo. Spain: J. Alvarez, M. de Nadal, S. Garcia del Valle, R. Gonzalez, S. González-Suárez, A. González-Tallada, M. Maestre, E. Mena, P. Plou, B. Tena, S. Sabate, and G. Urrutia. United Kingdom: P. Balaji, N. Hemmings, M. Vizcaychipi, and I. Wrench. United States: D. Ai, H. Arora, S. Bergese, J. Cata, R. Coombs, H. Honar, P. Kumar, A. Kurz, S. Martinelli, R. McKay, S. Melibary, S. Memtsoudis, S. Miller, E. Nemergut, A. Podolyak, V. Salmasi, D. Sessler, and A. Uribe.