Almost 2 decades after the introduction of noninvasive positive pressure
ventilation (NPPV), researchers continue to try to catch up with the necessary
evaluation to answer key clinical questions about this intervention. For instance,
should NPPV be used in patients with acute respiratory failure? If so, do
some patients benefit more than others? Can NPPV ever cause harm in this setting?
While the puzzle is not complete, each study contributes a new piece that
provides a glimpse of the big picture. Two studies, in this issue of the THE
JOURNAL1,2 provide important data
on the effectiveness of NPPV in acute respiratory failure.
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