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Comment & Response |

Erythropoietin for Traumatic Brain Injury

Alistair Nichol, MB, BCh, PhD1; Lorraine Little, BHSc (Nursing), MBioethics2; Craig French, MBBS3
[+] Author Affiliations
1Department of Critical Care Medicine, University College Dublin, Dublin, Ireland
2Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
3Department of Intensive Care, Western Health, Victoria, Australia
JAMA. 2014;312(18):1928-1929. doi:10.1001/jama.2014.12738.
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To the Editor Dr Robertson and colleagues1 conducted a 2 × 2 factorial design randomized clinical trial of 200 patients with traumatic brain injury to test the effect of 2 approaches to transfusion threshold and erythropoietin therapy on neurological outcome. Unfortunately, their findings that erythropoietin failed to demonstrate an outcome benefit reflect substantial lack of statistical power.


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November 12, 2014
Claudia S. Robertson, MD; Jose-Miguel Yamal, PhD; Barbara C. Tilley, PhD
1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas
2University of Texas School of Public Health, Houston
JAMA. 2014;312(18):1929. doi:10.1001/jama.2014.12744.
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