The association between infant age at initiation of hepatitis B vaccination
and completion of the 3-dose hepatitis B vaccination series is unclear.
To assess the association between administration of the first dose of
hepatitis B vaccine within 7 days of birth and completion of the hepatitis
B vaccine series and the 4:3:1:3 vaccine series (4 doses of diphtheria-tetanus-pertussis
vaccine, 3 doses of polio vaccine, 1 dose of measles-containing vaccine, and
3 doses of Haemophilus influenzae type b vaccine).
Design, Setting, and Participants
Analysis of data from the 1998 National Immunization Survey, a random-digit-dialing
telephone survey (n = 34,480 completed interviews) of parents of children
aged 19 to 35 months from 50 states and 28 selected urban areas in the United
States that included a provider record check mail survey.
Main Outcome Measures
Percentage of infants who received at least 3 doses of hepatitis B vaccine
and percentage who received the 4:3:1:3 vaccine series, by age at receipt
of the first dose of hepatitis B vaccine.
Overall, 86.9% of children 19 to 35 months of age in 1998 received 3
or more doses of hepatitis B vaccine, and 79.9% completed the 4:3:1:3 vaccine
series. Multivariate analysis indicated that, compared with children who received
the first hepatitis B vaccine dose within 7 days of birth, odds ratios (ORs)
for not completing the 3-dose hepatitis B vaccine series among children who
received the first dose at 8 to 41 days, 42 to 91 days, 92 to 182 days, 183
to 273 days, and 274 or more days of age were 2.4 (95% confidence interval
[CI], 2.0-3.0), 7.8 (95% CI, 6.5-9.3), 9.6 (95% CI, 7.0-13.3), 18.3 (95% CI,
12.0-28.0), and 46.6 (95% CI, 33.7-64.5), respectively; ORs for not completing
the 4:3:1:3 vaccine series among these same groups were 1.0 (95% CI, 0.8-1.1),
1.0 (95% CI, 0.8-1.1), 1.7 (95% CI, 1.3-2.3), 3.8 (95% CI, 2.6-5.6), and 4.0
(95% CI, 2.9-5.5), respectively.
Administration of the first dose of hepatitis B vaccine at birth is
associated with increased likelihood of completion of the hepatitis B vaccination