Fifty years ago, THE JOURNAL published 2 articles1,2
that were among the first of what was to become a deluge of epidemiological
studies linking tobacco use to adverse health outcomes. These early studies
on tobacco and disease established the basis for assessing disease causality
and led to the conclusion that tobacco use is directly responsible for more
than 25 causes of death.3 In the last 2 decades,
this epidemiological evidence for disease causation has been complemented
by evidence of economic harm.
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Web of Science® Times Cited: 17
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