In this population-based analysis, Biggar and colleagues linked data
from 4954 children aged 14 years and younger at AIDS diagnosis to cancer registry
data in 11 US geographic areas. One hundred twenty-four children (2.5%) were
identified as having cancer before, at, or after AIDS onset. The most frequently
occurring cancer was non-Hodgkin lymphoma (100 cases), followed by Kaposi
sarcoma (8 cases), leiomyosarcoma (4 cases), and Hodgkin disease (2 cases).
For all cancer types identified, the number of observed cancers among children
with AIDS during the 2 years after AIDS onset exceeded the expected number
of cancers based on population rates.