Editorial |

Ancrod—Is Snake Venom an Antidote for Stroke?

Marc R. Mayberg, MD; Anthony Furlan, MD
JAMA. 2000;283(18):2440-2442. doi:10.1001/jama.283.18.2440.
Text Size: A A A
Published online


Elevated serum fibrinogen levels have been associated with poor outcome in patients with acute ischemic stroke.1 Although the causality and specific mechanisms of the relationship between increased fibrinogen and stroke remain speculative, it has been proposed that lower fibrinogen levels after stroke may accelerate spontaneous fibrinolysis, inhibit thrombus propagation, promote the release of endogenous tissue-type plasminogen activator (tPA), or improve local cerebral blood flow through diminished viscosity.2 Ancrod is a protease derived from Malaysian pit viper venom that produces rapid decreases in serum fibrinogen by accelerating cleavage of the fibrinogen A-α chain.3 Ancrod has been shown to be effective in limiting infarction volume in animal models of acute stroke4 and in a randomized clinical trial.5,6

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 7

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles

Users' Guides to the Medical Literature

Users' Guides to the Medical Literature
Mild Stroke