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Effects of Mental Stress in Patients With Coronary Artery Disease:  Evidence and Clinical Implications

David S. Krantz, PhD; David S. Sheps, MD; Robert M. Carney, PhD; Benjamin H. Natelson, MD
JAMA. 2000;283(14):1800-1802. doi:10.1001/jama.283.14.1800.
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There is increasing recognition in the medical and scientific communities of the importance of behavioral and psychosocial factors in the prevention, development, and treatment of cardiovascular disorders.1 The purpose of this article is to review the evidence and mechanisms for the effects of acute and chronic stress in individuals with preexisting coronary artery disease (CAD), and evidence for the efficacy of psychosocial interventions in patients with CAD.

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