Few public health problems have captured the attention of the biomedical
and lay communities alike as has Alzheimer disease (AD). As the new millennium
begins, it is becoming increasingly clear that a great many people will escape
other major causes of mortality to reach the age when neurodegenerative diseases,
particularly AD, become highly prevalent. To avoid an exacerbation of the
personal and societal tragedy that AD already represents, clinicians and researchers
must accurately define its cause and early pathogenesis and develop effective
interventions, preferably agents that prevent the onset of symptoms. The study
by Näslund et al1 in this issue of THE
JOURNAL provides compelling evidence that the accumulation of small protein
fragments called amyloid β-peptides (Aβ) in brain regions subserving
memory and cognition is a very early pathogenic event that precedes both neurological
impairment and the development of the other proteinaceous lesion of AD, the
neurofibrillary tangle. Moreover, the authors show that the conversion from
a presymptomatic to a symptomatic state and the subsequent progression of
dementia correlate significantly with a dramatic increase in brain Aβ
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 186
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.