In this analysis of the cost-effectiveness of the pneumococcal conjugate
vaccine, Lieu and colleagues estimated that vaccination of healthy infants
would prevent more than 12,000 cases of meningitis and bacteremia, 53,000
cases of pneumonia, 1 million episodes of otitis media, and 116 deaths. Considering
direct medical costs and work-loss and productivity costs, routine infant
pneumococcal vaccination would result in net savings if the vaccine cost less
than $46 per dose.