A number of striking changes have occurred recently in the presentation
and course of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency
syndrome (AIDS) who are receiving highly active antiretroviral therapy (HAART).
Before the use of HAART, CMV retinitis was the most common intraocular infection
in patients with AIDS, occurring in up to 40% of patients, typically when
CD4+ cell counts have decreased to less than 0.10 × 109/L. By studying CMV retinitis, clinicians can investigate whether the
rejuvenated immune system that results from HAART can effectively control
opportunistic infections in patients with AIDS. In some patients, retinitis
has not progressed when specific anti-CMV therapy was discontinued, but a
number of patients have developed substantial intraocular inflammation, which
has resulted in decreased visual acuity. Anterior uveitis, cataract, vitritis,
cystoid macular edema, epiretinal membrane, and disc edema may occur in patients
with CMV retinitis who have experienced HAART-associated elevation in CD4+ cell counts. Since immune recovery uveitis does not occur in eyes
without CMV retinitis, the ocular inflammation appears to be related to the
CMV infection. Anti-CMV maintenance therapy likely can be safely discontinued
in some patients with CMV retinitis if CD4+ cell counts are stable
or increasing and have been higher than 0.10 × 109/L for
at least 3 months. Immune recovery in patients receiving HAART has been effective
in controlling opportunistic infections, but it may also result in intraocular
inflammation, which can have adverse effects on the eye.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 50
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Care at the Close of Life EDUCATION GUIDESOvercoming the False Dichotomy of Curative vs Palliative Care for Late-Stage HIV/AIDS
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.