We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Cardiac Assessment Before Stem Cell Transplantation for Systemic Sclerosis

Richard K. Burt, MD1; Maria Carolina Oliveira, MD2; Sanjiv J. Shah, MD3
[+] Author Affiliations
1Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois
2Division of Clinical Immunology, University of São Paulo, Ribeirão Preto, Brazil
3Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA. 2014;312(17):1803. doi:10.1001/jama.2014.12566.
Text Size: A A A
Published online


To the Editor The key to safe hematopoietic stem cell transplantation in patients with systemic sclerosis is a careful pretransplant cardiac assessment and subsequent recognition and management of cardiac complications.1 In the Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial by Dr van Laar and colleagues,2 the main exclusion criteria for cardiac reasons were left ventricular ejection fraction less than 45% and pulmonary arterial hypertension, defined as a mean pulmonary artery pressure greater than 50 mm Hg by echocardiogram or cardiac catheterization.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




November 5, 2014
Jacob M. van Laar, MD, PhD; Dominique Farge, MD, PhD; Alan Tyndall, MD
1Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands
2Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Paris, France
3Department of Rheumatology, University Hospital Basel, Basel, Switzerland
JAMA. 2014;312(17):1803-1804. doi:10.1001/jama.2014.12572.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...