Meta-analysis, done properly, is a systematic effort to search for and
winnow out all the best evidence and show how well a given intervention works.
It is crucially dependent on the identification of all available data from
clinical trials. In 1989, Gøtzsche,1
who was performing a meta-analysis of 244 trials of nonsteroidal anti-inflammatory
drugs in rheumatoid arthritis, drew attention to a practice that seemed to
subvert the normal process of publication as well as of meta-analysis. Excluding
abstracts, letters, and brief versions, Gøtzsche found 44 multiple
publications of 31 of the clinical trials, 20 trials published twice, 10 three
times, and 1 trial 5 times, with the overall proportion of multiple publications
being at least 18%. The fact that the data had been published elsewhere was
not noted in 32 of the 44 articles. Indeed, in about half of them, the first
author and number of authors were different, and in half there were important
discrepancies between the various versions of the same trial. Gøtzsche1 pointed out that "some cases were so difficult to
detect that in a meta-analysis they might have been mistaken for separate
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 90
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.