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Comment & Response |

Insulin vs Sulfonylureas for Second-Line Diabetes Treatment—Reply

Monika M. Safford, MD1
[+] Author Affiliations
1Department of Medicine, University of Alabama, Birmingham
JAMA. 2014;312(16):1695-1696. doi:10.1001/jama.2014.11129.
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In Reply Dr Roumie and colleagues have clarified the interpretation of their analysis of unmeasured confounder imbalance in their study.1 Because their analysis reported absolute differences, as they point out in their letter, the prevalence of unmeasured confounders would need to be quite high in the insulin-treated group with little or no prevalence in the sulfonylurea-treated group to explain the findings of their study.


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October 22, 2014
Christianne L. Roumie, MD, MPH; Robert A. Greevy, PhD; Marie R. Griffin, MD, MPH
1Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research, Education Clinical Center, HSR&D Center, Nashville
2Department of Biostatistics, Vanderbilt University, Nashville, Tennessee
3Department of Health Policy, Vanderbilt University, Nashville, Tennessee
JAMA. 2014;312(16):1694. doi:10.1001/jama.2014.11126.
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