The human immunodeficiency virus type 1 (HIV-1) epidemic, like the virus
itself, continues to evolve. Over the last several years, the development
of combination antiretroviral chemotherapy, able to suppress plasma virus
to undetectable levels in many infected individuals, has led to a profound
change in the epidemic, at least in the developed world. Both mortality and
morbidity of HIV-1–infected individuals have been decreasing secondary
to these combinations of antiretroviral agents, referred to as highly active
antiretroviral therapy (HAART).1- 3
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