We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Benefits and Risks Associated With Thrombolysis for Pulmonary Embolism—Reply

Saurav Chatterjee, MD1; Jay Giri, MD, MPH2
[+] Author Affiliations
1Division of Cardiology, St Luke’s-Roosevelt Hospital, New York, New York
2Cardiovascular Medicine Division, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA. 2014;312(15):1589-1590. doi:10.1001/jama.2014.10789.
Text Size: A A A
Published online


In Reply Dr Bradford and colleagues suggest that the Peto method of determination of pooled ORs may be flawed because the event rates for mortality in pulmonary embolism trials were approximately 3%. However, at event rates less than 5%, the Peto method provides the least biased estimates of treatment effect when compared with the corrected Mantel-Haenszel, DerSimonian-Laird, and inverse-variance ORs.1


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




October 15, 2014
Mark A. Bradford, MD; Neill K. J. Adhikari, MDCM, MSc; Jan O. Friedrich, MD, DPhil
1Section of Pulmonary and Critical Care Medicine, Boston University School of Medicine, Boston, Massachusetts
2Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
3Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
JAMA. 2014;312(15):1588-1589. doi:10.1001/jama.2014.10780.
October 15, 2014
Carlo Bova, MD
1Department of Internal Medicine, Azienda Ospedaliera di Cosenza, Cosenza, Italy
JAMA. 2014;312(15):1589. doi:10.1001/jama.2014.10786.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...