Grahic Jump Location
Microarrays allow scientists to compare gene expression in normal
and tumor cells. A robot places tiny droplets containing gene fragments on
a glass slide, creating a panel for the analysis of gene activity. Genetic
material from normal and tumor tissues is extracted and transcribed into complementary
DNA (cDNA), which is then labeled with fluorescent dyes. If a cDNA "probe"
binds to a gene fragment on the slide, this indicates that the gene in the
tissue specimen is active. A specialized scanning microscope measures the
intensity of each fluorescent spot, which is an indicator of the degree to
which a specific gene is expressed in a particular tissue. (Credit: National
Human Genome Research Institute)
Progression of loss of 18F-dopa storage in an initially asymptomatic
identical twin of a patient with PD who 5 years later became clinically affected.
(Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a normal subject, a relative who was
asymptomatic but subclinically affected by PD, and a patient clinically affected
by PD. (Credit: David Brooks, MD)
Basal ganglia and thalamic retention of PK11195, a marker of activated
microglial cells, in a patient with PD indicates the presence of an active
inflammatory response to the disease. (Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a patient with PD at baseline and again
2 years later shows clear loss of dopamine storage along with clinical progression
on the Unified Parkinson's Disease Rating Scale. (Credit: David Brooks, MD)
Grahic Jump Location
Microarrays allow scientists to compare gene expression in normal
and tumor cells. A robot places tiny droplets containing gene fragments on
a glass slide, creating a panel for the analysis of gene activity. Genetic
material from normal and tumor tissues is extracted and transcribed into complementary
DNA (cDNA), which is then labeled with fluorescent dyes. If a cDNA "probe"
binds to a gene fragment on the slide, this indicates that the gene in the
tissue specimen is active. A specialized scanning microscope measures the
intensity of each fluorescent spot, which is an indicator of the degree to
which a specific gene is expressed in a particular tissue. (Credit: National
Human Genome Research Institute)
Progression of loss of 18F-dopa storage in an initially asymptomatic
identical twin of a patient with PD who 5 years later became clinically affected.
(Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a normal subject, a relative who was
asymptomatic but subclinically affected by PD, and a patient clinically affected
by PD. (Credit: David Brooks, MD)
Basal ganglia and thalamic retention of PK11195, a marker of activated
microglial cells, in a patient with PD indicates the presence of an active
inflammatory response to the disease. (Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a patient with PD at baseline and again
2 years later shows clear loss of dopamine storage along with clinical progression
on the Unified Parkinson's Disease Rating Scale. (Credit: David Brooks, MD)
Grahic Jump Location
Microarrays allow scientists to compare gene expression in normal
and tumor cells. A robot places tiny droplets containing gene fragments on
a glass slide, creating a panel for the analysis of gene activity. Genetic
material from normal and tumor tissues is extracted and transcribed into complementary
DNA (cDNA), which is then labeled with fluorescent dyes. If a cDNA "probe"
binds to a gene fragment on the slide, this indicates that the gene in the
tissue specimen is active. A specialized scanning microscope measures the
intensity of each fluorescent spot, which is an indicator of the degree to
which a specific gene is expressed in a particular tissue. (Credit: National
Human Genome Research Institute)
Progression of loss of 18F-dopa storage in an initially asymptomatic
identical twin of a patient with PD who 5 years later became clinically affected.
(Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a normal subject, a relative who was
asymptomatic but subclinically affected by PD, and a patient clinically affected
by PD. (Credit: David Brooks, MD)
Basal ganglia and thalamic retention of PK11195, a marker of activated
microglial cells, in a patient with PD indicates the presence of an active
inflammatory response to the disease. (Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a patient with PD at baseline and again
2 years later shows clear loss of dopamine storage along with clinical progression
on the Unified Parkinson's Disease Rating Scale. (Credit: David Brooks, MD)
Grahic Jump Location
Microarrays allow scientists to compare gene expression in normal
and tumor cells. A robot places tiny droplets containing gene fragments on
a glass slide, creating a panel for the analysis of gene activity. Genetic
material from normal and tumor tissues is extracted and transcribed into complementary
DNA (cDNA), which is then labeled with fluorescent dyes. If a cDNA "probe"
binds to a gene fragment on the slide, this indicates that the gene in the
tissue specimen is active. A specialized scanning microscope measures the
intensity of each fluorescent spot, which is an indicator of the degree to
which a specific gene is expressed in a particular tissue. (Credit: National
Human Genome Research Institute)
Progression of loss of 18F-dopa storage in an initially asymptomatic
identical twin of a patient with PD who 5 years later became clinically affected.
(Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a normal subject, a relative who was
asymptomatic but subclinically affected by PD, and a patient clinically affected
by PD. (Credit: David Brooks, MD)
Basal ganglia and thalamic retention of PK11195, a marker of activated
microglial cells, in a patient with PD indicates the presence of an active
inflammatory response to the disease. (Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a patient with PD at baseline and again
2 years later shows clear loss of dopamine storage along with clinical progression
on the Unified Parkinson's Disease Rating Scale. (Credit: David Brooks, MD)
Grahic Jump Location
Microarrays allow scientists to compare gene expression in normal
and tumor cells. A robot places tiny droplets containing gene fragments on
a glass slide, creating a panel for the analysis of gene activity. Genetic
material from normal and tumor tissues is extracted and transcribed into complementary
DNA (cDNA), which is then labeled with fluorescent dyes. If a cDNA "probe"
binds to a gene fragment on the slide, this indicates that the gene in the
tissue specimen is active. A specialized scanning microscope measures the
intensity of each fluorescent spot, which is an indicator of the degree to
which a specific gene is expressed in a particular tissue. (Credit: National
Human Genome Research Institute)
Progression of loss of 18F-dopa storage in an initially asymptomatic
identical twin of a patient with PD who 5 years later became clinically affected.
(Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a normal subject, a relative who was
asymptomatic but subclinically affected by PD, and a patient clinically affected
by PD. (Credit: David Brooks, MD)
Basal ganglia and thalamic retention of PK11195, a marker of activated
microglial cells, in a patient with PD indicates the presence of an active
inflammatory response to the disease. (Credit: David Brooks, MD)
Striatal 18F-dopa uptake in a patient with PD at baseline and again
2 years later shows clear loss of dopamine storage along with clinical progression
on the Unified Parkinson's Disease Rating Scale. (Credit: David Brooks, MD)