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Comment & Response |

PET Screening for Metastatic Colorectal Adenocarcinoma—Reply

Carol-Anne Moulton, MB, BS1; Karen Gulenchyn, MD2; Mark N. Levine, MD2
[+] Author Affiliations
1University Health Network, Toronto, Ontario
2McMaster University, Hamilton Health Sciences, Hamilton, Ontario
JAMA. 2014;312(12):1256-1257. doi:10.1001/jama.2014.9853.
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In Reply Drs Wong and Jolepalem and Dr Hofman and colleagues question the value of PET after preoperative chemotherapy. In our trial, a baseline CT was used to decide if the patient was a candidate for hepatic surgery. Most patients (70%) had received prior chemotherapy, usually adjuvant, for their primary treatment and often at a time and place remote from study enrollment. Patients were considered eligible 4 weeks after their last chemotherapy dose. This was a real-life study and reflects standard referral patterns. It does not seem in a patient’s best interest to delay a PET-CT for many months to achieve better resolution of the test.

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September 24, 2014
Ching-yee Oliver Wong, MD, PhD; Prashant Jolepalem, MD
1Department of Diagnostic Radiology and Molecular Imaging, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan
JAMA. 2014;312(12):1255-1256. doi:10.1001/jama.2014.9844.
September 24, 2014
Michael S. Hofman, MBBS, FRACP; Robert E. Ware, MBBS, FCP; Benjamin N. Thomson, MBBS, FRACS
1Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia
2Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
JAMA. 2014;312(12):1255-1256. doi:10.1001/jama.2014.9850.
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