0
Editorial |

Progress in Understanding Ventilator-Induced Lung Injury

Leonard D. Hudson, MD
JAMA. 1999;282(1):77-78. doi:10.1001/jama.282.1.77.
Text Size: A A A
Published online

Extract

The concept of ventilator-induced lung injury (VILI) has come of age. The concept that the manner in which patients with acute lung injury and the acute respiratory distress syndrome (ARDS) have been supported with conventional mechanical ventilation is responsible for worsening the extent of the lung injury has been suggested by compelling animal model data.17 However, justification for this concept in human studies is limited to 1 relatively small randomized controlled trial in which reducing tidal volume decreased 28-day mortality, but hospital discharge mortality was not affected.8 Other studies in which the tidal volume is limited have had negative results.9,10 Without further evidence in humans, it seemed possible that VILI would prove to be yet another hypothesis based on animal model data that was not confirmed in humans. Now, exciting news from studies in humans suggests that VILI is a clinically relevant process.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 18

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();