Study concept and design: Castellucci, Cameron, Coyle, Carrier.
Acquisition, analysis, or interpretation of data: Castellucci, Cameron, Le Gal, Rodger, P.S. Wells, Clifford, Gandara, G. Wells, Carrier.
Drafting of the manuscript: Castellucci, Cameron, Rodger, Gandara, Carrier.
Critical revision of the manuscript for important intellectual content: All Authors.
Statistical analysis: Cameron, Coyle, Gandara, G. Wells, Carrier.
Administrative, technical, or material support: Clifford, Carrier.
Study supervision: Le Gal, Coyle, Clifford, G. Wells, Carrier.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Le Gal reports receiving payment for lectures from Biomerieux, Bayer, Pfizer, and Sanofi. Dr Wells reports receiving payments for speaker fees from Bayer, Boehringer Ingelheim, Biomerieux, and Bristol-Myers Squibb/Pfizer. Dr Rodger reports receiving research grants from Biomerieux. Dr Carrier reports receiving research grants from Leo Pharma and Bristol-Myers Squibb. Drs Castellucci, Cameron, George Wells, Coyle, Gandara, and Clifford had no financial disclosures to report.
Funding/Support: Dr Carrier is a recipient of a New Investigator Award from the Heart and Stroke Foundation of Canada and holds a T2 Research Chair in Cancer and Thrombosis form the University of Ottawa. Dr Cameron is a recipient of grant CGV 121171. a Vanier Canada Graduate Scholarship from the Canadian Institutes of Health Research and has received funding from Canadian Network and Centre for Trials Internationally (CANNeCTIN). He is also a trainee on Network Meta-analysis Team grant (116573) through the CIHR Drug Safety and Effectiveness Network. Dr Rodger is the recipient of a Career Scientist Award from the Heart and Stroke Foundation of Ontario. Dr Philip S. Wells is a recipient of a Canada Research Chair in Venous Thromboembolism.
Role of Funder/Sponsor: The funding organizations did not have any role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.