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Comment & Response |

Recurrence Rates in Autism Spectrum Disorders

John N. Constantino, MD1
[+] Author Affiliations
1Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
JAMA. 2014;312(11):1154-1155. doi:10.1001/jama.2014.9841.
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To the Editor The recent report by Dr Sandin and colleagues1 contributes to a converging body of recent research specifying recurrence rates in autism spectrum disorders (ASD) by analyzing data from a large epidemiological birth cohort in Sweden.

The results included a large-scale confirmation that the sex of the proband does not predict familial recurrence risk, indicating that the Carter effect (increased familial recurrence among subsets of cases [eg, females] who have been hypothesized to require higher than usual genetic loading to express the disorder), which was observed for subclinical autistic-like traits in a sample from the United Kingdom and Sweden,2 may not apply to a majority of clinical autistic syndromes.


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September 17, 2014
Sven Sandin, PhD; Abraham Reichenberg, PhD
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
2Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, New York
JAMA. 2014;312(11):1155. doi:10.1001/jama.2014.9847.
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