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A New Source of Resistance to HIV Drugs

Mark A. Wainberg, PhD
JAMA. 1999;281(23):2169-2170. doi:10.1001/jama.281.23.2169.
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Extract

Journal Scan Archive
November 1998
http://www.ama-assn.org/AIDS
Posted January 26, 1999

Winters MA, Coolley KL, Girard YA.  et al. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. J Clin Invest.1998;102:1769-1775.
Shirasaka T, Kavlick MF, Ueno T.  et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci U S A.1995;92:2398-2402.
Iversen AK, Shafer RW, Wehrly K.  et al. Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy. J Virol.1996;70:1086-1090.
De Jong JJ, Jurriaans S, Goudsmit J.  et al. Insertion of two amino acids in reverse transcriptase during antiretroviral combination therapy: implications for resistance against nucleoside RT inhibitors.In: Program and abstracts of the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies; June 24-27, 1998; Lake Maggiore, Italy. Abstract 18.
Bloor S, Hertogs K, Desmer RL.  et al. Virological basis for HIV-1 resistance to stavudine investigated by analysis of clinical samples.In: Program and abstracts of the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies; June 24-27, 1998; Lake Maggiore, Italy. Abstract 15.
Whitcomb JM, Limoli K, Wrin T.  et al. Phenotypic and genotypic analysis of stavudine-resistant isolates of HIV-1.In: Program and abstracts of the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies; June 24-27, 1998; Lake Maggiore, Italy. Abstract 17.
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