Inclusion of the patient perspective in research need not, and must not, reduce the rigor of the research. Patient input informs the design of research components that are already a standard part of studies, such as inclusion/exclusion criteria, comparators, and outcomes. The special training and skill set of researchers guide the approaches to study design, data collection, and analysis, just as the experience and perspectives of patients, clinicians, and other stakeholders help to make the research more patient-centered and relevant to health care decisions. Physician input is needed because patient-centered outcomes research is intended to influence clinical practice. There are practical reasons to incorporate patient-centeredness in research, including improved choice of research questions and improved selection and refinement of outcomes through elicitation of stakeholder perspectives, enhanced accrual and participant retention strategies, and more appropriate dissemination and implementation strategies for findings. The promise of speeding implementation is particularly salient for PCORI, which has a legislative mandate to improve practice and reduce practice variation and disparities. PCORI proposals must include an implementation plan. Clinicians have a role in putting results into practice and should be aware of the intention of patient-centered research to enhance relevance and, ideally, trust in results by those who use them.