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Comment & Response |

Treatments for Pediatric Status Epilepticus

Alison Poulton, MD, MBBChir, MA1; Deepak Kumar Rai, MD, DCh2; Kate Venter, MBBS, BMedSci2
[+] Author Affiliations
1Sydney Medical School Nepean, University of Sydney, Sydney, Australia
2Department of Paediatrics, Nepean Hospital, Sydney, Australia
JAMA. 2014;312(9):962. doi:10.1001/jama.2014.8745.
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To the Editor The study by Dr Chamberlain and colleagues1 found that lorazepam was not more efficacious than diazepam for children with status epilepticus. We would appreciate further clarification regarding analysis of outcomes with reference to age and etiology.

We noted the high percentage of participants with febrile convulsions, especially within the younger age groups (3 months-<3 years and 3 years-<13 years). We also noted that in the age group older than 13 years there appeared to be more children who responded within 10 minutes to lorazepam (90.9%) than to diazepam (69.2%). It is therefore possible that lorazepam might be more effective for nonfebrile seizures in older children, but this analysis was limited by small numbers of patients.


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September 3, 2014
James M. Chamberlain, MD; Traci Clemons, PhD
1Division of Emergency Medicine, Children’s National Medical Center, Washington, DC
2Emmes Corporation, Rockville, Maryland
JAMA. 2014;312(9):963. doi:10.1001/jama.2014.8755.
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